{"id":145,"date":"2026-09-26T13:24:53","date_gmt":"2026-09-26T13:24:53","guid":{"rendered":"https:\/\/sachastaliklari.org.tr\/?page_id=145"},"modified":"2026-09-26T13:31:25","modified_gmt":"2026-09-26T13:31:25","slug":"sistemik-enfeksiyonlarin-sac-tutulumu-sekonder-sifilis-frengi-ve-moth-eatenguve-yenigi-dokulme","status":"publish","type":"page","link":"https:\/\/sachastaliklari.org.tr\/?page_id=145","title":{"rendered":"Sistemik Enfeksiyonlar\u0131n Sa\u00e7 Tutulumu (Sekonder Sifilis \/ Frengi ve &#8220;Moth-eaten&#8221;g\u00fcve yeni\u011fi D\u00f6k\u00fclme)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"145\" class=\"elementor elementor-145\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2179801 e-flex e-con-boxed e-con e-parent\" data-id=\"2179801\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d3a2834 elementor-widget elementor-widget-html\" data-id=\"d3a2834\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<article class=\"medical-guide-page\">\r\n    <h1>Sistemik Enfeksiyonlar\u0131n Sa\u00e7 Tutulumu (Sekonder Sifilis \/ Frengi ve \"Moth-eaten\" D\u00f6k\u00fclme) \u2013 Tan\u0131 ve Tedavi Rehberi<\/h1>\r\n    <p class=\"author-meta\"><strong>Haz\u0131rlayan:<\/strong> Dr. Muhammet \u00d6zgehan | T\u00fcrkiye Sa\u00e7 ve Sa\u00e7 Deri Hastal\u0131klar\u0131 Derne\u011fi<\/p>\r\n    <p class=\"compilation-meta\"><em>Bu rehber, Dr. Muhammet \u00d6zgehan taraf\u0131ndan derlenmi\u015ftir.<\/em><\/p>\r\n\r\n    <!-- Ortam K\u00fct\u00fcphanesinden Eklenen Medikal \u0130ll\u00fcstrasyon -->\r\n    <div class=\"medical-illustration-container\" style=\"margin: 20px 0; text-align: center;\">\r\n        <img decoding=\"async\" src=\"https:\/\/sachastaliklari.org.tr\/wp-content\/uploads\/2026\/09\/sistemik-enfeksiyonlar-sekonder-sifiliz-guve-yemis-alopesi-dr-muhammet-ozgehan.png\" alt=\"Sistemik Enfeksiyon Sekonder Sifilis Sa\u00e7 D\u00f6k\u00fclmesi Klinik \u0130ll\u00fcstrasyonu\" style=\"max-width: 100%; height: auto; border-radius: 8px; box-shadow: 0 4px 12px rgba(0,0,0,0.1);\">\r\n    <\/div>\r\n\r\n    <section class=\"patient-info\">\r\n        <h2>\ud83d\udccc Hasta Bilgilendirme B\u00f6l\u00fcm\u00fc: Bu Durum Ne Anlama Geliyor?<\/h2>\r\n        <p>Cinsel yolla bula\u015fan sistemik bir enfeksiyon olan frenginin (sifilis) ikinci evresinde, v\u00fccudun genelinde g\u00f6r\u00fclen belirtilere ek olarak sa\u00e7l\u0131 deride \u00e7ok karakteristik bir sa\u00e7 d\u00f6k\u00fclmesi tablosu ortaya \u00e7\u0131kabilir.<\/p>\r\n        <ul>\r\n            <li><strong>Moth-Eaten (G\u00fcve Yemi\u015f Gibi) D\u00f6k\u00fclme Nedir?:<\/strong> Sa\u00e7l\u0131 deride, \u00f6zellikle oksipital (ense) ve temporal (\u015fakak) b\u00f6lgelerde keskin s\u0131n\u0131rl\u0131 olmayan, bozuk para b\u00fcy\u00fckl\u00fc\u011f\u00fcnde birden fazla k\u00fc\u00e7\u00fck, da\u011f\u0131n\u0131k sa\u00e7 d\u00f6k\u00fclme odaklar\u0131 olu\u015fur. G\u00f6r\u00fcnt\u00fc sanki g\u00fcve yemi\u015f bir kuma\u015fa benzer.<\/li>\r\n            <li><strong>Di\u011fer Bulgular\u0131:<\/strong> Avu\u00e7 i\u00e7i ve ayak tabanlar\u0131nda soluk k\u0131rm\u0131z\u0131 d\u00f6k\u00fcnt\u00fcler, yayg\u0131n lenf bezi \u015fi\u015flikleri ve a\u011f\u0131z i\u00e7i lezyonlar e\u015flik edebilir.<\/li>\r\n            <li><strong>Ne Yapmal\u0131?:<\/strong> Bu tablo sistemik bir hastal\u0131\u011f\u0131n habercisidir. Yerel sa\u00e7 tedavileri i\u015fe yaramaz; erken d\u00f6nemde serolojik testler yap\u0131lmal\u0131 ve penisilin tedavisi ba\u015flanmal\u0131d\u0131r.<\/li>\r\n        <\/ul>\r\n    <\/section>\r\n\r\n    <section class=\"doctor-guide\">\r\n        <h2>\ud83e\ude7a Hekimler \u0130\u00e7in Klinik & Medikal K\u0131lavuz<\/h2>\r\n        <ul>\r\n            <li><strong>Etyoloji ve Patofizyoloji:<\/strong> Spiroket t\u00fcr\u00fc olan *Treponema pallidum* bakterisinin sistemik yay\u0131l\u0131m\u0131. K\u0131l folik\u00fcllerini \u00e7evreleyen damarlarda endarterit ve buna ba\u011fl\u0131 iskemik\/enflamatuar sa\u00e7 d\u00f6k\u00fclmesi (non-skatrisyel alopesi).<\/li>\r\n            <li><strong>Tan\u0131 Kriterleri ve Klinik Bulgular:<\/strong> Sekonder sifilis hastalar\u0131n\u0131n yakla\u015f\u0131k %4-7'sinde g\u00f6r\u00fclen \"moth-eaten\" (g\u00fcnde yemi\u015f gibi) tipte alopesi. Ka\u015flar\u0131n lateral k\u0131sm\u0131nda d\u00f6k\u00fclme e\u015flik edebilir. Serolojik olarak VDRL\/RPR ve TPHA\/TPPA pozitifli\u011fi.<\/li>\r\n            <li><strong>Dermoskopi (Trikoskopi) Bulgular\u0131:<\/strong> Siyah nokta (k\u0131r\u0131k sa\u00e7 u\u00e7lar\u0131) yoklu\u011fu, bo\u015f folik\u00fcler ostiumlar, korunmu\u015f interfolik\u00fcler epidermis ve sar\u0131ms\u0131-pembede zemin \u00fczerinde telanjiyektatik damar paternleri.<\/li>\r\n            <li><strong>Histopatolojik Tan\u0131 (Punch Biyopsisi):<\/strong> \r\n                <ul>\r\n                    <li><em>Biyopsi Endikasyonu:<\/em> Alopeci areata ile kar\u0131\u015fan atipik olgularda \u015f\u00fcphelenildi\u011finde lezyondan 4 mm punch biyopsi al\u0131n\u0131r.<\/li>\r\n                    <li><em>Patoloji:<\/em> Perivask\u00fcler ve perifolk\u00fcler alanda plazmositlerden zengin yo\u011fun infiltrat (plazmosit infiltrasyonu sifilis i\u00e7in olduk\u00e7a tipiktir) ve endarterit bulgular\u0131.<\/li>\r\n                <\/ul>\r\n            <\/li>\r\n            <li><strong>G\u00fcncel Tedavi Protokolleri:<\/strong> \r\n                <ul>\r\n                    <li><em>Sistemik Tedavi:<\/em> Benzatin Penisilin G 2.4 milyon \u00fcnite IM tek doz (sekonder evrede). Penisilin alerjisi olanlarda Doksisiklin veya Azitromisin. Tedaviyle birlikte sa\u00e7lar birka\u00e7 ay i\u00e7inde kendili\u011finden tamamen geri \u00e7\u0131kar (skars\u0131zd\u0131r). Ayr\u0131ca klinik ve cerrahi de\u011ferlendirmeler i\u00e7in <a href=\"https:\/\/www.muhammetozgehan.com.tr\" target=\"_blank\" rel=\"noopener\">uzmanl\u0131k ve tedavi yakla\u015f\u0131mlar\u0131<\/a> incelenebilir.<\/li>\r\n                <\/ul>\r\n            <\/li>\r\n        <\/ul>\r\n    <\/section>\r\n\r\n    <section class=\"scientific-references\" style=\"margin-top: 40px; padding-top: 20px; border-top: 1px solid #eaeaea;\">\r\n        <h3>Bilimsel Referanslar ve Daha Fazla Bilgi<\/h3>\r\n        <ul style=\"font-size: 0.95em; line-height: 1.6;\">\r\n            <li>Dai S, Wang H, Lin Z. Moth-eaten alopecia in secondary syphilis. <em>Int J Infect Dis<\/em>. 2019 May;82:6. doi: 10.1016\/j.ijid.2019.02.023. Epub 2019 Feb 23. PMID: 30807867. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30807867\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n            <li>Saraswat N, Tripathy DM, Kumar S, Ranjan E, Madakshira MG, Goel S. Malignant secondary syphilis presenting with rupioid lesions and moth-eaten alopecia. <em>Indian J Sex Transm Dis AIDS<\/em>. 2024 Jan-Jun;45(1):82-83. doi: 10.4103\/ijstd.ijstd_73_23. Epub 2024 Jun 6. PMID: 38989088; PMCID: PMC11233054. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38989088\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n            <li>Jordaan HF, Louw M. The moth-eaten alopecia of secondary syphilis. A histopathological study of 12 patients. <em>Am J Dermatopathol<\/em>. 1995 Apr;17(2):158-62. doi: 10.1097\/00000372-199504000-00008. PMID: 8600781. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8600781\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n        <\/ul>\r\n    <\/section>\r\n<\/article>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Sistemik Enfeksiyonlar\u0131n Sa\u00e7 Tutulumu (Sekonder Sifilis \/ Frengi ve &#8220;Moth-eaten&#8221; D\u00f6k\u00fclme) \u2013 Tan\u0131 ve Tedavi Rehberi Haz\u0131rlayan: Dr. Muhammet \u00d6zgehan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-145","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=145"}],"version-history":[{"count":4,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/145\/revisions"}],"predecessor-version":[{"id":149,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/145\/revisions\/149"}],"wp:attachment":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}