{"id":151,"date":"2026-09-26T13:37:27","date_gmt":"2026-09-26T13:37:27","guid":{"rendered":"https:\/\/sachastaliklari.org.tr\/?page_id=151"},"modified":"2026-09-26T20:07:05","modified_gmt":"2026-09-26T20:07:05","slug":"lepra-cuzzam-ve-granulomatoz-hastaliklarda-sac-derisi-tutulumu","status":"publish","type":"page","link":"https:\/\/sachastaliklari.org.tr\/?page_id=151","title":{"rendered":"Lepra (C\u00fczzam) ve Gran\u00fclomat\u00f6z Hastal\u0131klarda Sa\u00e7 Derisi Tutulumu"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"151\" class=\"elementor elementor-151\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6639088 e-flex e-con-boxed e-con e-parent\" data-id=\"6639088\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-faba95e elementor-widget elementor-widget-html\" data-id=\"faba95e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<article class=\"medical-guide-page\">\r\n    <h1>Lepra (C\u00fczzam) ve Gran\u00fclomat\u00f6z Hastal\u0131klarda Sa\u00e7 Derisi Tutulumu \u2013 Tan\u0131 ve Tedavi Rehberi<\/h1>\r\n    <p class=\"author-meta\"><strong>Haz\u0131rlayan:<\/strong> Dr. Muhammet \u00d6zgehan | T\u00fcrkiye Sa\u00e7 ve Sa\u00e7 Deri Hastal\u0131klar\u0131 Derne\u011fi<\/p>\r\n    <p class=\"compilation-meta\"><em>Bu rehber, Dr. Muhammet \u00d6zgehan taraf\u0131ndan derlenmi\u015ftir.<\/em><\/p>\r\n\r\n    <!-- Ortam K\u00fct\u00fcphanesinden Eklenen Medikal \u0130ll\u00fcstrasyon -->\r\n    <div class=\"medical-illustration-container\" style=\"margin: 20px 0; text-align: center;\">\r\n        <img decoding=\"async\" src=\"https:\/\/sachastaliklari.org.tr\/wp-content\/uploads\/2026\/09\/leprosy-hansen-disease-granulomatous-diseases-scalp-dr-muhammet-ozgehan.png\" alt=\"Lepra Hansen Hastal\u0131\u011f\u0131 Gran\u00fclomat\u00f6z Sa\u00e7 Derisi Tutulumu \u0130ll\u00fcstrasyonu\" style=\"max-width: 100%; height: auto; border-radius: 8px; box-shadow: 0 4px 12px rgba(0,0,0,0.1);\">\r\n    <\/div>\r\n\r\n    <section class=\"patient-info\">\r\n        <h2>\ud83d\udccc Hasta Bilgilendirme B\u00f6l\u00fcm\u00fc: Bu Durum Ne Anlama Geliyor?<\/h2>\r\n        <p>Lepra (c\u00fczzam \/ Hansen hastal\u0131\u011f\u0131), *Mycobacterium leprae* bakterisinin yol a\u00e7t\u0131\u011f\u0131, periferik sinirleri ve deriyi tutan kronik gran\u00fclomat\u00f6z bir enfeksiyon hastal\u0131\u011f\u0131d\u0131r. Nadir g\u00f6r\u00fclse de sa\u00e7l\u0131 deride ve y\u00fczde karakteristik k\u0131l kay\u0131plar\u0131na yol a\u00e7abilir.<\/p>\r\n        <ul>\r\n            <li><strong>Sa\u00e7 ve Ka\u015f Tutulumu:<\/strong> Lepran\u0131n \u00f6zellikle lepromat\u00f6z formunda, ka\u015flar\u0131n d\u0131\u015f k\u0131sm\u0131ndan ba\u015flayarak d\u00f6k\u00fclmesi (madarozis) ve sa\u00e7l\u0131 deride gran\u00fclomat\u00f6z nod\u00fcller, plaklar ile birlikte kal\u0131c\u0131 sa\u00e7 kay\u0131plar\u0131 geli\u015febilir.<\/li>\r\n            <li><strong>Di\u011fer Bulgular\u0131:<\/strong> Deride duyu kayb\u0131 (s\u0131cak-so\u011fuk ve a\u011fr\u0131 hissinin kayboldu\u011fu soluk lekeler), kulak memesinde kal\u0131nla\u015fma, sinir tutulumlar\u0131 ve y\u00fczde asimetrik bulgular.<\/li>\r\n            <li><strong>Ne Yapmal\u0131?:<\/strong> \u00c7oklu ila\u00e7 kombinasyonlar\u0131yla (MDT - Multidrug therapy) tamamen tedavi edilebilen bir hastal\u0131kt\u0131r. Erken te\u015fhis kal\u0131c\u0131 sinir hasarlar\u0131n\u0131 \u00f6nlemek i\u00e7in hayati \u00f6nem ta\u015f\u0131r.<\/li>\r\n        <\/ul>\r\n    <\/section>\r\n\r\n    <section class=\"doctor-guide\">\r\n        <h2>\ud83e\ude7a Hekimler \u0130\u00e7in Klinik & Medikal K\u0131lavuz<\/h2>\r\n        <ul>\r\n            <li><strong>Etyoloji ve Patofizyoloji:<\/strong> *Mycobacterium leprae* veya *Mycobacterium lepromatosis* etkendir. Basiller serin v\u00fccut b\u00f6lgelerini (kulak memesi, burun mukozas\u0131, sa\u00e7l\u0131 derinin periferi) tercih eder. K\u0131l folik\u00fcllerini ve sinir u\u00e7lar\u0131n\u0131 gran\u00fclomat\u00f6z iltihapla infiltre ederek skatrisyel veya non-skatrisyel alopesilere neden olur.<\/li>\r\n            <li><strong>Tan\u0131 Kriterleri ve Klinik Bulgular:<\/strong> Ka\u015flar\u0131n lateral 1\/3'\u00fcn\u00fcn d\u00f6k\u00fclmesi (Madarozis), sa\u00e7l\u0131 deride infiltratif lezyonlar, nod\u00fcller ve duyu kusuru olan lezyonlar. B\u00fcy\u00fck aurik\u00fcler sinir kal\u0131nla\u015fmalar\u0131.<\/li>\r\n            <li><strong>Histopatolojik Tan\u0131 (Punch Biyopsi):<\/strong> \r\n                <ul>\r\n                    <li><em>Biyopsi Endikasyonu:<\/em> \u015e\u00fcpheli gran\u00fclomat\u00f6z sa\u00e7 derisi veya y\u00fczde yer alan lezyonlardan 4 mm punch biyopsi al\u0131n\u0131r.<\/li>\r\n                    <li><em>Patoloji:<\/em> Dermiste epiteloid h\u00fccreler, Virchow h\u00fccreleri (k\u00f6p\u00fcks\u00fc makrofajlar) ve lenfositlerden olu\u015fan gran\u00fclomlar. Fite-Faraco veya Ziehl-Neelsen boyamas\u0131 ile intrasell\u00fcler basil k\u00fcmelerinin (globi) g\u00f6sterilmesi.<\/li>\r\n                <\/ul>\r\n            <\/li>\r\n            <li><strong>G\u00fcncel Tedavi Protokolleri:<\/strong> \r\n                <ul>\r\n                    <li><em>\u00c7oklu \u0130la\u00e7 Tedavisi (MDT):<\/em> D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc (WHO) protokol\u00fcne uygun olarak Rifampisin, Dapson ve Klofazimin kombinasyonlar\u0131 (hastal\u0131k tipine g\u00f6re 6 ay ila 2 y\u0131l s\u00fcreyle) kesintisiz uygulan\u0131r. Ayr\u0131ca klinik ve cerrahi de\u011ferlendirmeler i\u00e7in <a href=\"https:\/\/www.muhammetozgehan.com.tr\" target=\"_blank\" rel=\"noopener\">uzmanl\u0131k ve tedavi yakla\u015f\u0131mlar\u0131<\/a> incelenebilir.<\/li>\r\n                <\/ul>\r\n            <\/li>\r\n        <\/ul>\r\n    <\/section>\r\n\r\n    <section class=\"scientific-references\" style=\"margin-top: 40px; padding-top: 20px; border-top: 1px solid #eaeaea;\">\r\n        <h3>Bilimsel Referanslar ve Daha Fazla Bilgi<\/h3>\r\n        <ul style=\"font-size: 0.95em; line-height: 1.6;\">\r\n            <li>Kaya D, Garnes ND, Robins A, Su SY, Ginsberg LE, Chen MM. Leprosy of the great auricular nerve: case report and review of the literature. <em>Clin Imaging<\/em>. 2022 Feb;82:63-66. doi: 10.1016\/j.clinimag.2021.10.001. Epub 2021 Oct 15. PMID: 34775253. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34775253\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n            <li>Concha R M, Cossio T ML, Salazar S I, Fich S F, P\u00e9rez C C, Gonz\u00e1lez B S. Enfermedad de Hansen: Revisi\u00f3n a prop\u00f3sito de un caso [Hansen's disease: case report and review of literature]. <em>Rev Chilena Infectol<\/em>. 2008 Feb;25(1):64-9. Spanish. PMID: 18273528. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18273528\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n            <li>Thaipisuttikul Y, Kateruttanakul P. Sarcoidosis mimics lepromatous leprosy: a case report. <em>J Med Assoc Thai<\/em>. 2007 Jan;90(1):171-4. PMID: 17621750. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17621750\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n        <\/ul>\r\n    <\/section>\r\n<\/article>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Lepra (C\u00fczzam) ve Gran\u00fclomat\u00f6z Hastal\u0131klarda Sa\u00e7 Derisi Tutulumu \u2013 Tan\u0131 ve Tedavi Rehberi Haz\u0131rlayan: Dr. Muhammet \u00d6zgehan | T\u00fcrkiye Sa\u00e7 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-151","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=151"}],"version-history":[{"count":10,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/151\/revisions"}],"predecessor-version":[{"id":221,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/151\/revisions\/221"}],"wp:attachment":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}