{"id":157,"date":"2026-09-26T13:49:46","date_gmt":"2026-09-26T13:49:46","guid":{"rendered":"https:\/\/sachastaliklari.org.tr\/?page_id=157"},"modified":"2026-09-27T14:55:25","modified_gmt":"2026-09-27T14:55:25","slug":"keratosis-pilaris-atrophicans-faciei-kpaf","status":"publish","type":"page","link":"https:\/\/sachastaliklari.org.tr\/?page_id=157","title":{"rendered":"Keratosis Pilaris Atrophicans Faciei (KPAF)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"157\" class=\"elementor elementor-157\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f29811d e-flex e-con-boxed e-con e-parent\" data-id=\"f29811d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-68d339a elementor-widget elementor-widget-html\" data-id=\"68d339a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<article class=\"medical-guide-page\">\r\n    <h1>Keratosis Pilaris Atrophicans Faciei (KPAF) \u2013 Tan\u0131 ve Tedavi Rehberi<\/h1>\r\n    <p class=\"author-meta\"><strong>Haz\u0131rlayan:<\/strong> Dr. Muhammet \u00d6zgehan | T\u00fcrkiye Sa\u00e7 ve Sa\u00e7 Deri Hastal\u0131klar\u0131 Derne\u011fi<\/p>\r\n    <p class=\"compilation-meta\"><em>Bu rehber, Dr. Muhammet \u00d6zgehan taraf\u0131ndan derlenmi\u015ftir.<\/em><\/p>\r\n\r\n    <!-- Ortam K\u00fct\u00fcphanesinden Eklenen Medikal \u0130ll\u00fcstrasyon -->\r\n    <div class=\"medical-illustration-container\" style=\"margin: 20px 0; text-align: center;\">\r\n        <img decoding=\"async\" src=\"https:\/\/sachastaliklari.org.tr\/wp-content\/uploads\/2026\/09\/keratosis-pilaris-atrophicans-faciei-kpaf-dr-muhammet-ozgehan.png\" alt=\"Keratosis Pilaris Atrophicans Faciei KPAF Klinik ve Medikal \u0130ll\u00fcstrasyonu\" style=\"max-width: 100%; height: auto; border-radius: 8px; box-shadow: 0 4px 12px rgba(0,0,0,0.1);\">\r\n    <\/div>\r\n\r\n    <section class=\"patient-info\">\r\n        <h2>\ud83d\udccc Hasta Bilgilendirme B\u00f6l\u00fcm\u00fc: Bu Durum Ne Anlama Geliyor?<\/h2>\r\n        <p>Keratosis Pilaris Atrophicans Faciei (KPAF), genellikle \u00e7ocukluk veya ergenlik d\u00f6neminde ba\u015flayan, k\u0131l folik\u00fcllerinin keratin ad\u0131 verilen sert bir maddeyle t\u0131kanmas\u0131 ve zamanla folik\u00fcl \u00e7evresinde kal\u0131c\u0131 atrofi (incelme\/\u00e7\u00f6k\u00fckl\u00fck) ve k\u0131l kay\u0131plar\u0131na yol a\u00e7an nadir bir kal\u0131tsal deri ve sa\u00e7\/ka\u015f hastal\u0131\u011f\u0131d\u0131r.<\/p>\r\n        <ul>\r\n            <li><strong>Nereleri Tutar?:<\/strong> En s\u0131k yanaklarda, kulak \u00f6n\u00fcnde ve ka\u015flar\u0131n d\u0131\u015f k\u0131s\u0131mlar\u0131nda k\u0131zar\u0131kl\u0131k, p\u00fct\u00fcrl\u00fcl\u00fck ve ard\u0131ndan kal\u0131c\u0131 k\u0131l d\u00f6k\u00fclmeleri (ka\u015flarda seyrelme) \u015feklinde g\u00f6r\u00fcl\u00fcr. Sa\u00e7l\u0131 deri s\u0131n\u0131rlar\u0131na da ta\u015fabilir.<\/li>\r\n            <li><strong>Belirtileri Nelerdir?:<\/strong> Ciltte z\u0131mba deli\u011fi tarz\u0131nda k\u00fc\u00e7\u00fck \u00e7ukurluklar (atrofi), folik\u00fcler pap\u00fcller ve kal\u0131c\u0131 t\u00fcy\/k\u0131l kay\u0131plar\u0131.<\/li>\r\n            <li><strong>Ne Yapmal\u0131?:<\/strong> Standart nemlendiriciler bu durumu geriletmez. Kal\u0131c\u0131 izlerin ve doku kay\u0131plar\u0131n\u0131n \u00f6n\u00fcne ge\u00e7mek i\u00e7in erken d\u00f6nemde dermatolojik takip ve keratoregulat\u00f6r tedaviler \u015fartt\u0131r.<\/li>\r\n        <\/ul>\r\n    <\/section>\r\n\r\n    <section class=\"doctor-guide\">\r\n        <h2>\ud83e\ude7a Hekimler \u0130\u00e7in Klinik & Medikal K\u0131lavuz<\/h2>\r\n        <ul>\r\n            <li><strong>Etyoloji ve Patofizyoloji:<\/strong> Folik\u00fcler epitelin anormal keratinizasyonu, folik\u00fcl ostiumunun t\u0131kanmas\u0131, folik\u00fcl i\u00e7inde keratin t\u0131kac\u0131 olu\u015fumu ve buna e\u015flik eden hafif inflamasyonun folik\u00fcler yap\u0131y\u0131 y\u0131karak skatrisyel (atropik) kayba yol a\u00e7mas\u0131 (Otozomal dominant ge\u00e7i\u015fli formlar\u0131 bildirilmi\u015ftir).<\/li>\r\n            <li><strong>Tan\u0131 Kriterleri ve Klinik Bulgular:<\/strong> Yanaklarda ve ka\u015f b\u00f6lgesinde simetrik eritemat\u00f6z folik\u00fcler pap\u00fcller, follik\u00fcler keratotik t\u0131ka\u00e7lar, ka\u015flar\u0131n lateralinde kal\u0131c\u0131 skatrisyel d\u00f6k\u00fclme ve y\u00fczde \"atropik \u00e7ukurluklar\" (vergetures \/ ice-pick benzeri izler). Frontal fibrosing alopesi ile ay\u0131r\u0131c\u0131 tan\u0131 gerekebilir.<\/li>\r\n            <li><strong>Dermoskopi (Trikoskopi) Bulgular\u0131:<\/strong> K\u0131l ostiumlar\u0131n\u0131 t\u0131kayan sar\u0131ms\u0131-beyaz keratin t\u0131kac\u0131 halkalar\u0131, etraflar\u0131nda peri-folik\u00fcler eritem ve fibrotik\/atropik beyaz alanlar (k\u0131l folik\u00fcllerinin yok oldu\u011fu alanlar).<\/li>\r\n            <li><strong>Histopatolojik Tan\u0131 (Punch Biyopsisi):<\/strong> \r\n                <ul>\r\n                    <li><em>Biyopsi Endikasyonu:<\/em> Atipik skatrisyel alopesiler ve folik\u00fcler keratozlarla kar\u0131\u015fan olgularda 4 mm punch biyopsi al\u0131n\u0131r.<\/li>\r\n                    <li><em>Patoloji:<\/em> \u0130nfundibulumda t\u0131kal\u0131 keratin t\u0131kac\u0131, folik\u00fcl duvar\u0131nda atrofi, dermiste elastik lif kayb\u0131 ve hafif perivask\u00fcler\/perifolk\u00fcler lenfositik infiltrat.<\/li>\r\n                <\/ul>\r\n            <\/li>\r\n            <li><strong>G\u00fcncel Tedavi Protokolleri:<\/strong> \r\n                <ul>\r\n                    <li><em>Keratolitik ve Retinoid Tedaviler:<\/em> Topikal retinoik asit, salisilik asit veya \u00fcre i\u00e7eren kremler ile keratin t\u0131ka\u00e7lar\u0131n\u0131n giderilmesi. Sistemik izotretinoin (d\u00fc\u015f\u00fck doz) se\u00e7ilmi\u015f diren\u00e7li vakalarda fibrozisi bask\u0131lamak i\u00e7in kullan\u0131labilir.<\/li>\r\n                    <li><em>Lazer ve Kozmetik Yakla\u015f\u0131mlar:<\/em> Eritem i\u00e7in vask\u00fcler lazerler, atrofik izler i\u00e7in fraksiyonel lazer (\u00f6rn. 585 nm diyot veya fraksiyonel kat\u0131 hal lazerler) uygulamalar\u0131. Ayr\u0131ca klinik ve cerrahi de\u011ferlendirmeler i\u00e7in <a href=\"https:\/\/www.muhammetozgehan.com.tr\" target=\"_blank\" rel=\"noopener\">uzmanl\u0131k ve tedavi yakla\u015f\u0131mlar\u0131<\/a> incelenebilir.<\/li>\r\n                <\/ul>\r\n            <\/li>\r\n        <\/ul>\r\n    <\/section>\r\n\r\n    <section class=\"scientific-references\" style=\"margin-top: 40px; padding-top: 20px; border-top: 1px solid #eaeaea;\">\r\n        <h3>Bilimsel Referanslar ve Daha Fazla Bilgi<\/h3>\r\n        <ul style=\"font-size: 0.95em; line-height: 1.6;\">\r\n            <li>Fekete GL, Fekete L, Neagu N, Bac\u00e2rea V, Dr\u0103g\u0103nescu M, Brihan I. Keratosis pilaris atrophicans faciei: An observational, descriptive, retrospective clinical study. <em>Exp Ther Med<\/em>. 2021 Nov;22(5):1331. doi: 10.3892\/etm.2021.10766. Epub 2021 Sep 20. PMID: 34630685; PMCID: PMC8495552. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34630685\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n            <li>G\u00f6n\u00fclal M, Karaca S, Balc\u0131 DD. Keratosis Pilaris Atrophicans Faciei: A Case Treated with 585 nm Diode Laser, a Novel Fractional Solid-State. <em>Clin Cosmet Investig Dermatol<\/em>. 2023 Dec 4;16:3497-3501. doi: 10.2147\/CCID.S441779. PMID: 38077919; PMCID: PMC10706048. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38077919\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n            <li>Desai DD, Nohria A, Shapiro J, Lo Sicco KI. Navigating Diagnostic Uncertainty: Frontal Fibrosing Alopecia Versus Keratosis Pilaris Atrophicans Faciei With Genetic Testing Insights. <em>Cureus<\/em>. 2024 Apr 23;16(4):e58830. doi: 10.7759\/cureus.58830. PMID: 38784309; PMCID: PMC11114203. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38784309\/\" target=\"_blank\" rel=\"noopener\">PubMed Linki<\/a><\/li>\r\n        <\/ul>\r\n    <\/section>\r\n<\/article>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Keratosis Pilaris Atrophicans Faciei (KPAF) \u2013 Tan\u0131 ve Tedavi Rehberi Haz\u0131rlayan: Dr. Muhammet \u00d6zgehan | T\u00fcrkiye Sa\u00e7 ve Sa\u00e7 Deri [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-157","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=157"}],"version-history":[{"count":7,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/157\/revisions"}],"predecessor-version":[{"id":233,"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=\/wp\/v2\/pages\/157\/revisions\/233"}],"wp:attachment":[{"href":"https:\/\/sachastaliklari.org.tr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}